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The reactive sulfhydryl group is added to the carboxylic acid end of 4-phosphopantothenate from cysteine via the action of phosphopantothenoylcysteine synthetase which is encoded by the PPCS gene
Endocr Pract
2016;133:S1524
(PubMed) However, while some small studies report mild pigment/lightening changes with glutathione (oral or topical), the clinical evidence for long-term, safe, and effective skin-whitening via IV glutathione is weak or absent
Problem is, aging (GSH levels start to decline around your 25th birthday) and dealing with the trials of everyday life can deplete your stores, and leave you more comatose than conscious
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