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The development of tirzepatide represents a significant advance beyond selective GLP-1 receptor agonists such as liraglutide, dulaglutide, and semaglutide, which have been the cornerstone of incretin-based therapy over the past decade (Fras et al

The medication is indicated as an adjunct to diet and exercise, either as monotherapy when metformin is contraindicated or not tolerated, or in combination with other glucose-lowering medications including metformin, sulfonylureas, sodium-glucose co-transporter-2 (SGLT-2) inhibitors, and insulin

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QZ and SU were trained within of the PhD program Metabolic and Cardiovascular Disease (DK-MCD) and Biomolecular Structures and Interactions (BioMolStruct)