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Glutathione peroxidase 4 (GPX4) is an essential peroxidase that suppresses ferroptosis, requiring glutathione (GSH) as a cofactor to catalyze the reduction of PL-OOH

With physician-compounded topical formulations used daily, patients consistently report improved skin texture and smoothness at weeks 2 to 4, increased firmness and reduced fine line visibility at weeks 6 to 10, better hydration and radiance that holds with continued use, and a gradual improvement in skin tone evenness over 3 to 6 months

Although we considered those as non-specific binding, it should be noted that GSH can bind proteins via stable, non-reducible, thioethers and these could account for some of these positive spots 28

Deficiency leads to nerve damage (neuropathy), which presents as numbness, tingling, or weakness