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Food and Drug Administration approved a GLP-1 drug, Wegovy, for use by adults with obesity or a weight-related condition

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Discuss with your clinician about adjusting your GLP-1 dosing schedule if constipation is severe Consider prescription medications for persistent constipation that doesnt respond to other measures When to seek medical advice Contact your healthcare provider if you experience: No bowel movement for more than 4-5 days Severe abdominal pain or distension Blood in the stool Constipation alternating with diarrhoea Unexplained weight loss or fatigue Constipation that doesnt improve with self-management strategies Long-term outlook For most patients, constipation either resolves as the body adjusts to GLP-1 therapy or can be effectively managed with dietary and lifestyle modifications

Ascorbate in chromaffin granules is then secreted concomitant with catecholamines from cultured chromaffin cells [47] and in vivo by human adrenal glands, the latter in response to adreno-corticotrophin stimulation [48]

Nutrients, 14 (17), 3629