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This metabolic switching is regulated by sirtuins, namely SIRT3 and SIRT2 repress the Warburg effect 342,343,344,345 , while SIRT5 maintains glycolysis 346

Adequate levels of B12 can help in maintaining a balanced mood and have been linked to a reduction in depression symptoms, underscoring the vitamins importance in mental health

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Disease can lower glutathione through inflammation, oxidative reactions, impaired synthesis, altered nutrient status, tissue damage or medication effects