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Key cited studies: Maquart FX et al
Impaired serine metabolism reduces H3K27 trimethylation on histones, which upregulates IGF1 and activates the p38JAK/STAT1 pathway to drive M1 polarization while inhibiting M2 polarization (115)
The therapeutic window appears well-established at these dosing levels, with higher doses unlikely to provide proportional additional benefits while potentially increasing adverse events
This is medical judgment, not sales pressure
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