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Nat Rev Neurosci Jun 2014;15(6):367-78
no MHRA or NICE guidance exists yet, as the drug remains investigational pending phase 3 results
This second incretin is produced by enteroendocrine L cells, which are diffusedly distributed in the distal gut mucosa of ileum and colon (25, 26) [ Figure 1 Section A]
Intracerebral approaches require surgical safety assessment, long-term imaging, and surveillance for ectopic tissue formation or tumorigenicity [41]
However, at least in early to mid-stage renal disease, lowering of the serum phosphate concentration is much more important in management than dietary protein restriction, and this can be easily accomplished with phosphate binders without lowering the protein content of the diet (25,26)
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