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At week 10, when mice reached the threshold fasting blood glycemic value of 200 mg/dl, the insulin-resistance onset sign, an additional group was derived from the HFD one to receive subcutaneously once a week for 6 weeks Semaglutide (SEMA- 30 nmol/kg
Convenience: A simple "stick-and-go" method could make adherence even easier
Microdosing modifies one or more elements of that pattern: Starting below 2.5 mg using specialized preparations under medical supervision, Stretching each titration step to many more weeks Choosing an intermediate maintenance dose, such as 5 mg or 7.5 mg, rather than escalating to 1015 mg Altering the injection frequency to smooth exposure
2013, 305 (2): E161-70
