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While effective for regulating periods and reducing androgen-related symptoms, contraceptives do not address the underlying metabolic dysfunction and are not suitable for women trying to conceive

In addition, they can also inhibit inflammation and oxidant-induced programmed cell death (e.g., apoptosis, necroptosis, pyroptosis) [64, 66, 67]

However, the control group (i.e., individuals with obesity not on these medications to treat type-2 diabetes or weight loss) reported these assessments for the current time point only

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Propensity-score matching is a method of mimicking some of the characteristics of a randomized controlled trial ( In addition, a variety of subgroup and sensitivity analyses confirmed the finding from the main analysis