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Zhang Y, Pak C, Han Y, Ahlenius H, Zhang Z, Chanda S, Marro S, Patzke C et al (2013) Rapid single-step induction of functional neurons from human pluripotent stem cells

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a class of drugs approved for treatment of type 2 diabetes (T2D), overweight, and obesity

Add electrolytes if needed to make increased water intake more palatable and to prevent electrolyte dilution

28% placebo Correlation: every 5kg weight loss -1.5 PHQ-9 points Independent effects: 40% improves weight loss, 60% provides additional mechanisms Tirzepatide SURMOUNT-1 (Mental Health Outcomes): Baseline depression (self-reported): 22% participants Improves depressive symptoms: 68% tirzepatide group vs

The bones analyzed included the proximal humerus (N=96), distal tibia (N=56), distal femur (N=34), and proximal tibia (N=28)