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Estrogen Exposure and Adipose-Driven Hormonal Modulation Because adipose tissue produces estrogen via aromatase, reductions in visceral fat can lower peripheral estrogen levels in some individuals
doi: 10.1016/S0140-6736(19)32517-6 Summary Keywords non-alcoholic steatohepatitis, nonalcoholic fatty liver disease, obesity, insulin resistance, metabolic syndrome, metabolic disease, fibroblast growth factor 21 Citation Tillman EJ and Rolph T (2020) FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases
AMPK enzyme activates, inhibiting mTOR (growth pathway) to favor cleanup
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In summary, the discovery of CYP51A1 as a conserved sterol 14-demethylase involved in cholesterol biosynthesis was achieved through decades of biochemical, genetic, and structural studies across species
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