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The precise role of this feature is not clear, but various possibilities have been suggested, including stabilisation of the peptide helical structure (Neidigh et al., 2001), facilitation of inter-protomer coupling within receptor oligomers (Koole et al., 2017), and protection against enzymatic degradation (Lee et al., 2018)
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Tirzepatide acts on GIP and GLP-1 receptors simultaneously (twincretin effect) to suppress appetite, enhance insulin release and sensitivity, and delay digestion to control blood sugar levels and reduce calorie intake
If a GLP-1 medication freezes, it must be discarded
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