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Benzyl alcohol has low acute toxicity with an LD50 of 1.2 g/kg in rats
Thus, hypoxia-generated ROS represents a fundamental pathogenic mechanism contributing to chemoresistance [480], ischemiareperfusion injury [481], chronic inflammation [482], and neurodegeneration [483]
Most drug candidates are in clinical development (45 out of 67, 67%) which is an encouraging sign that investment in basic research has paid off, uncovering therapeutic avenues now being actively pursued
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