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Dogs have a comparable gastric acid secretory profile, a similar mucosal defense architecture, and they develop spontaneous GI disease, not just experimentally induced disease
Rarely, they may persist longer
16 May 2018 medlineplus.gov - Vitamin B12 [Internet]
It did both of these things while crossing the blood-brain barrier and maintaining a plasma half-life exceeding 6 hours, which means sustained brain exposure from a single administration
Those with naturally high NNMT activity might respond more dramatically to inhibition, while those with lower baseline activity might see more modest effects
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