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The reason may be that high glutaminase expression favors rapid conversion of glutamine to glutamate for use in tricarboxylic acid cycle or bio-synthesis of nucleotides and other amino acids

We knock out Gipr in either the area postrema (AP) or hypothalamus of mice (Gipr AP-KO and Gipr hypo-KO , respectively) and compare body weight and food intake responses to GIPR agonists and antagonists, alone and in combination with the GLP-1R agonist liraglutide

Los frmacos agonistas GLP-1 se desarrollaron originalmente para tratar a personas con diabetes tipo 2 y su uso clnico comenz a mediados de los 2000

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