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Theyre also pretty common and historically very safein fact, the FDA has approved several transdermal patches designed to help people stop smoking, for example

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References 6B3J: Liang YL, Khoshouei M, Glukhova A, Furness SGB, Zhao P, Clydesdale L, Koole C, Truong TT, Thal DM, Lei S, Radjainia M, Danev R, Baumeister W, Wang MW, Miller LJ, Christopoulos A, Sexton PM, Wootten D

The result is a terminal elimination half-life of 165168 hours (approximately 7 days), enabling the once-weekly dosing schedule that defines semaglutide's clinical utility