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Moreover, vitamin C enhances neutrophil and lymphocyte activity, limits neutrophil necrosis and extracellular trap formation, and modulates nuclear responses to hypoxia and stress by regulating HIF-1 and inducing NF-B-related epigenetic changes (Fisher et al., 2011
XiangWWangWDuLZhaoBLiuXZhangXet al
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N.BesterJ
In this line, the authors of one of the first studies on programmed erythrocyte death demonstrated that erythrocytes from patients with different forms of anemia (sickle cell anemia, thalassemia, and G6PDdeficiency) are more susceptible toward oxidative stress as compared with erythrocytes from healthy volunteers
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