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At -80C, stability extends significantly
Historically, CV outcomes trials for antidiabetic medications relied on placebo-controlled studies to secure an FDA label for CV risk reduction
The growth hormone and IGF-1 it triggers continue working in the body well beyond that window, which is why once-daily dosing is effective despite the short half-life
The regulatory loophole permitted licensed compounders to make "essentially a copy" of approved drugs during shortages, but that permission ended when the FDA declared the shortage over
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