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Patients may also experience extra-intestinal manifestations, such as joint pain, skin rashes (e.g., erythema nodosum), eye inflammation (uveitis), and oral ulcers
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Often, long-term exposure may create serious consequences such as breakdown in digestive, immune, and neurological functions
However, in one study, the use of a low dosage of metformin in combination with conventional ATT did not accelerate sputum culture conversion, which could be attributed to insufficient dosing [123]
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