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Compared with the shrimp fed 084 mg/kg Se at low salinity, the DEG in the negative control diet at low salinity were significantly enriched in the metabolic pathways of retinol metabolism, steroid hormone biosynthesis and multiple carbohydrate metabolism-related pathways (e.g., pentose, glucuronic acid conversion, biosynthesis of other O-glycans and biosynthesis of glutenin-type O-glycans)