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An essential enzyme in the gamma-glutamyl cycle

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(Li et al., 2018), Arthrobacter globiformis M30 (Yoshihara et al., 2017), Clostridium cellulolyticum H10 (Su et al., 2018), Sinorhizobium sp

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Because these compounds are naturally occurring peptides with restricted patentability, opportunities for intellectual property protection and industry-sponsored development are limitedposing substantial barriers to the resource-intensive clinical investigations required to confirm therapeutic efficacy and long-term safety