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GLP-1 medications are not safe for everyone

[1] The effects of carfentanil, including overdose, can be reversed by the opioid antagonists naloxone and naltrexone, though higher doses than usual may be necessary compared to other opioids

Severe and potentially life-threatening reactions like pancreatitis, bowel obstruction or infection of the gallbladder are also possible, although less common

Rapid weight loss often leads to loose, sagging skin and a noticeable decline in elasticity

Data availability The atomic coordinates and the electron microscopy maps have been deposited in the Protein Data Bank (PDB) under accession number 7D68 and Electron Microscopy Data Bank (EMDB) under accession number EMD-30590, respectively