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Ascorbate transport by primary cultured neurons and its role in neuronal function and protection against excitotoxicity
Cons The glutathione supplier is not named
Second, targeting eryptosis pathways offers new therapeutic opportunities: strategies to mitigate eryptosis could include optimizing clearance of eryptosis-inducing uremic toxins via advanced dialysis modalities (e.g., hemodialysis combined with hemadsorption [HA + HD] for protein-bound uremic toxins) or novel pharmacotherapies, such as inhibitors of Organic Anion Transporter 2 (OAT2) to block indoxyl sulfate uptake by erythrocytes, antioxidants (e.g., N-acetyl-L-cysteine, vitamin E) to counteract oxidative stress-mediated eryptosis, or modulators of Ca 2+ signaling (e.g., NO donors) to stabilize erythrocyte membrane asymmetry
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Some of these medications (liraglutide, semaglutide, and dulaglutide) have demonstrated cardiovascular benefits in clinical trials, with Wegovy specifically approved for reducing cardiovascular risk in adults with established cardiovascular disease and either obesity or overweight
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