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This work was funded by: TS (Baylor College of Medicine, U01-AI24290, P01-AI152999, NINR R01-NR013497, and NIDDK P30-DK56338), SJW (NIDDK 1R41DK119052-01 and NIA P30-AG024832 [PI: E

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Risks include: Contamination with bacteria or fungi Endotoxin (bacterial cell wall fragments) that remain even after sterilization Severe inflammatory reactions or sepsis D

However, this approach is not routine first-line treatment in UK practice, is considered off-label, and requires good patient adherence and clinical follow-up

If stored below 30C (room temperature) and protected from light, contents may be used for 60 days after initial broaching of the vial