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A clinical trial investigated the effect of 8-week metformin treatment on aging individuals with mild cognitive impairment (MCI) or early AD, and the results revealed that metformin is associated with improved executive function, companied by improvement in learning/memory and attention [27]
Cells were seeded in complete medium consisting of RPMI-1640 supplemented with 10% FCS (Sigma), 1% Penicillin/Streptomycin (GIBCO), 1% L-Glutamine (Sigma), and 55 mM -mercaptoethanol (GIBCO)
2018 Sep 5;157:1500-1511
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