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I am under metabolic stress

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Decreased NAD + levels can contribute to sirtuin mediated deacetylase-dependent alterations in both mitochondrial electron transport activity (resulting in increased production of reactive oxygen species, ROS) as well as to increased nuclear DNA damage leading to the activation poly-ADP-ribose polymerases (PARP)

Some of those effects are expected and well documented

And glutathione depletion is a consistent finding across virtually all autoimmune conditions. Heres what Ive learned in my practice: immune tolerance the ability of your immune system to recognize your own tissues and NOT attack them isnt just inherited