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Because it creates that rewarding effect, it can encourage repeated and, in some cases, abusive use of the drug

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Glucagon-like Peptide-1 receptor activation in the ventral tegmental area decreases the reinforcing efficacy of cocaine

31 Clinically, GLP-1 RA use in patients with diabetes is associated with significant primary risk reduction of several obesity-associated cancers

The calculator uses these factors alongside published dose-response curves from the STEP and SURMOUNT trial programs to estimate your trajectory