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46 High intratumoral expression of CYP3A4 can accelerate the metabolic inactivation of chemotherapeutic agents such as paclitaxel and docetaxel, thereby reducing local drug bioavailability, diminishing therapeutic efficacy, and ultimately contributing to drug resistance
It contains a hydrophobic pocket which binds Leu, Ile, or Phe residues 17 from peptides adopting an extended conformation interacting through hydrogen bonds with a conserved glutamine (Q89)
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