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History of severe allergic reactions to semaglutide or tirzepatide
In terms of DPN, there is growing evidence that GLP-1 RAs provide neuroprotective effects, which may help limit or slow the progression of neuropathy in some patients
Lipase and amylase levels may become elevated in some patients, though routine monitoring in asymptomatic patients is not recommended
has received speakers honoraria from Janssen WA reports consultancy and sponsored lectures from Gilead, GlaxoSmithKline, Intercept IQVIA and UCB Pharma
Structurally, it features a 31-amino acid backbone with key chemical modifications: an alpha-aminobutyric acid (Aib) substitution at position 8 to confer resistance to dipeptidyl peptidase-4 (DPP-4) enzymatic cleavage, and a C-18 fatty diacid side chain linked via a hydrophilic spacer at Lys26
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