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The Lancet Diabetes & Endocrinology, 8(5), 377-391
doi: 10.1002/mds.27466 21
Trial data from these studies have shown improved weight-related outcomes compared with other treatments
Together, these results suggest that the activation of OB GLP-1R leads to an increase in insulin secretion through inhibition of SNS activity
However, the trend has also been linked to a reduction in behavioural health interventions , which raises significant clinical concerns
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