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That might mean focusing more on lifestyle changes, switching medications, or considering bariatric surgery. For some patients, surgical options such as sleeve gastrectomy may be appropriate, particularly if they want a more durable intervention

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2022 (atherosclerosis RCT): A clinical trial in 157 individuals aged 5875 with metabolic syndrome who received 1 g L-carnitine or placebo twice daily for 6 months found that total cholesterol and LDL cholesterol levels were higher in participants taking L-carnitine

And tirzepatide is now approved to treat obstructive sleep apnea (OSA)

This differential response to rapamycin suggests that EE may also stimulate MyHC-S isoform expression through mTOR-independent pathway(s)