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Statements Author contributions MK: Data curation, Investigation, Software, Writing original draft, Writing review and editing
Importantly, never reduce or stop insulin abruptly when starting GLP-1 therapy, as this carries a risk of diabetic ketoacidosis
biology 10(11):1165 Ugar M, Tufan AN, Altun M, Guclu K, Ozyurek M (2018) Glutathione peroxidase activity of biological samples using a novel microplate-based method
The most robust clinical evidence arguably originates from the large cardiovascular outcomes trials (CVOTs) completed for most GLP-1 RAs, of which the latest showed a significant relative risk reduction (RRR) of 39% (HR) with once-weekly efpeglenatide on HF requiring hospitalisation, corroborating a meta-analysis which found a significant RRR across eight GLP-1 RA CVOTs of 11%
In these cases, those funds might be better directed towards investments, savings, or other long-term plans that offer personal benefit and flexibility
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