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No validated human protocols exist
10.1038/aps.2014.41 60 LinM.ZhaiX.WangG.TianX.GaoD.ShiL.et al (2015)
This can contribute to fatigue, reduced muscle mass, menstrual irregularities in women, and decreased bone density
Once activated, ERK1/2 is transferred to the nucleus, where it phosphorylates transcription factors such as c-Myc and c-Fos, leading to the expression of genes responsible for cellular regulations such as cell proliferation, differentiation, and migration
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