Direct answer: Not broadly for obesity alone today
TD Cowen said in a January note that retatrutide could bring in $3.8 billion in sales by 2030
Receptor Activity Comparison GLP-1 Receptor Primary Effects: Appetite suppression, insulin secretion, gastric emptying delay Relevance to Bulking: Controls caloric intake, improves nutrient timing GIP Receptor Primary Effects: Enhanced insulin response, fat metabolism, nausea reduction Relevance to Bulking: Better nutrient partitioning, improved tolerance Glucagon Receptor Primary Effects: Increased energy expenditure, fat oxidation, thermogenesis Relevance to Bulking: Preferential fat burning, metabolic rate support The GLP-1 receptor activation provides appetite regulation that many lifters find invaluable during body composition phases
Care runs through a required video visit with a board-certified obesity medicine provider before anything is prescribed, then video visits every six months with messaging in between
This effect, combined with an anti-androgenic action at receptor sites (pharmacological toxicity), can result in gynaecomastia and decreased libido
