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The most commonly known substrates of GSTs are xenobiotic synthetic chemicals

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PlexusDx recommends consulting with an obstetrician or fertility specialist before combining weight loss therapy with pregnancy planning

More serious but rare complications include pancreatitis, gallbladder disease, and worsening of diabetic retinopathy (particularly with rapid improvement in blood glucose)

While overuse of these medications can be problematic, when prescribed and monitored by a healthcare provider, they have been studied for their potential role in supporting weight management and overall metabolic health