GSH is also involved in the neutralization of lipid aldehydes (4-HNE, MDA) generated by mitochondrial lipid peroxidation
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This transfer restores neutrophil bioenergetics via mitochondrial fusion, thereby inhibiting the formation of neutrophil extracellular traps (NETs) and breaking the cycle of NET-induced endothelial ferroptosis, which ultimately promotes angiogenesis and repair (Lu et al., 2024)
The primer efficiencies for the genes tested were between 98100%, therefore, changes in gene expression were calculated using the 2 CT method (Schmittgen and Livak, 2008)