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reported receiving grants from the Israel Science Foundation outside the submitted work

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Notably, PGRMC1 also binds other cytochrome P450 enzymes, such as cytochrome P450 family 3 subfamily A member 4 (CYP3A4), suggesting that individual variability in PGRMC1 function may influence broader drug metabolism pathways [49]

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Studied for melanogenesis and pigmentation pathways

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Repeated inadvertent ingestion of supratherapeutic doses may be especially dangerous, due to subacute depletion of hepatic glutathione stores

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Edited by Professor Dagmar Kulms Supplementary information Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made

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