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The asparagine-glycine sequence forms a cyclic imide intermediate that can hydrolyze into either aspartate or iso-aspartate, fundamentally altering the peptide structure

The disulfide in protein can be cleaved by reducing agents such as beta-mercaptoethanol, dithiothreitol, tris (2-carboxyethyl) phosphine (TCEP) or oxidizing agents which further oxidizes the disulfide to separate cysteic acids

Smith BM, Kawut SM, Bluemke DA, Basner RC, Gomes AS, Hoffman E, et al

Historic nucleic acids isolated by Friedrich Miescher contain RNA besides DNA

Helicobacter pylori -derived outer membrane vesicles (OMVs): role in bacterial pathogenesis