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Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis
( D ) Representative Western blots demonstrating that ALOX15 KD also decreases GPX4 protein expression ( n = 4)
N Engl J Med (2020) 383(23):221929
Pro-inflammatory cytokines increase neuronal vulnerability to apoptosis and oxidative stress by activating enzymes such as JNK, ERK, dsRNA-dependent protein kinase (PKR), and IB kinase (IKK) that reduce insulin sensitivity by serine phosphorylation of IRS1 [144, 145]
Hodson, D
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