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This is because growth factors can potentially encourage tumors to grow

Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, Kiyosue A, Zhang S, Liu B, Bunck MC, Stefanski A (2022) SURMOUNT-1 Investigators

The peptide works through a mechanism entirely separate from traditional HGH therapy , binding to the ghrelin receptor (GHS-R1a) and activating intracellular calcium signaling rather than the cAMP pathway used by GHRH