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This is due to the gastric emptying delaying effect of short-acting agents, and the gastric emptying delaying effect of long-acting agents gradually decreases due to tachyphylaxis, thereby reducing the effect of postprandial glycemic control
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In MIN6B1 cells, cAMP production after extended treatment with exendin-4 and exendin-asp3 was marginally reduced compared to the vehicle (Fig
