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Addition of leptin to GLP-1/glucagon co-agonism leads to greater weight loss and reductions in food intake in DIO mice compared to GLP-1/glucagon co-agonism monotherapy ( 30 )
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In meta-analyses and randomised trials, thiazolidinediones showed an increased risk of heart failure, heart failure hospitalization or death, weight gain, lower extremity oedema, and increased cardiovascular risk [43]
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