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We estimated the extent of mitochondrial damage in these cells via transmission electron microscopy (TEM) (Fig

Mechanism (for clinical insight) GLP-1 receptor agonist Appetite (central satiety) Gastric emptying Glucose-dependent insulin secretion Glucagon This mechanism underlies both glycemic benefit and weight reduction

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Retatrutide simultaneously activates GLP-1, GIP, and glucagon receptors, distinguishing it from licensed agents such as semaglutide or tirzepatide