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Nathan DM, Genuth S, Lachin J, et al
Obesity and Metabolic Research.
Ontario, British Columbia, Alberta, and Quebec each maintain separate formulary processes
Based on mechanism similarities and preliminary data, regain rates are expected to be comparable or slightly less severe, possibly because the metabolic rate improvements take longer to fully reverse
Consequently, VRK2 expression emerges as a dual-function biomarker: its targeted inhibition shows therapeutic efficacy in VRK2-high malignancies, while its deficiency serves as a predictive indicator for metabolic-targeted interventions
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