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Each addition introduces potential for interactions, stability concerns, and cost increases
The central marker is IGF-1, which reflects growth hormone activity
All mice were approved by the Laboratory Animal Welfare Ethics committee at Harbin Institute of Technology (Approval No: IACUC- 2024138) and conducted in accordance with the Guide for Care and Use of Laboratory Animals and the institutional ethical guidelines for animal experiments
Nature (2012) 489:23141
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