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All it takes is for some sleepy, overworked person to put the wrong box in the wrong place and connect that hose
2018;11(suppl 1):1358
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This protocol was applied to exacerbate metabolic impairment in the models of PCOS, commonly seen in this syndrome, and as a means to define adverse conditions where to test the therapeutic potential of the selected multi-agonists
A concrete example that clarifies this boundary is gastrin: multiple adequately powered human trials demonstrated that gastrin-based therapies failed to preserve beta-cell function in type 2 diabetes, and development was largely discontinued by approximately 2010
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