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Notably, we recently conducted LNP-mediated knock-in of the GFP gene at the Alb locus, with GFP expression predominantly observed in hepatocytes, further confirming that hepatocytes are primary target for LNP-mediated gene delivery and genome editing 13

If levels of oxalate in the glomerular filtrate increase (hyperoxaluria) it can chelate Ca 2+ ions forming the insoluble compound, calcium oxalate