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But seek medical attention for: Severe or persistent vomiting (especially if you can't keep down liquids) Severe abdominal pain , particularly in your upper left abdomen (could indicate pancreatitis) Signs of dehydration (dark urine, dizziness, extreme thirst) Bloody or black stools Unexplained, rapid weight loss beyond what's expected Symptoms that don't improve after the first month or two The Bigger Picture I want to be clear

Class B GPCRs, includ-ing the GLP-1R, are activated by endogenous peptide hormones, and the development of small-molecule agonists of these receptors has proven to be particularly challenging

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During the drug development process, researchers observed that high doses of GLP-1 agonists caused a rare type of thyroid cancer, known as Medullary Thyroid Cancer (MTC), in rats and mice

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