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Despite this shared mechanism, the two receptors exhibit distinct expression patterns and physiological roles that are genuinely complementary: When both axes are activated concurrently, the cAMP response in pancreatic -cells exceeds that of either agonist alone, indicating synergistic rather than merely additive intracellular signaling

Sakou FE-L, Reine, et al (2021)

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In the case of the glutathione group, the mMASI fell from 9.94 to 7.26 in the 4 th week, 7.26 to 4.94 in the 8 th week, and from 4.94 to 4.08 at the end of the study