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In the recent exenatide trial [34], the difference in weight loss between the exenatide and placebo groups was 0.5 kg, which is lower than the 2.0 kg difference observed in a previous randomised trial [32]
These findings suggest that most of the autoimmune risk is mediated through transcriptional regulation rather than protein dysfunction
Cost comparison and savings options for GLP-1s GLP-1 medications can be extremely costly if you need to pay for them out-of-pocket, without insurance
The ongoing Phase 3 trials will provide longer-duration data to confirm this possibility
O'Donoghue ML, Fazio S, Giugliano RP, et al
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